Volume 2, Issue 1 (January 2023)                   Health Science Monitor 2023, 2(1): 30-38 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ataei M, Akbarian Firoozabadi M, Abdollahi S, Hashemnejad M. Screening prenatal depression to assess childbirth and neonatal complications: a cohort study. Health Science Monitor 2023; 2 (1) :30-38
URL: http://hsm.umsu.ac.ir/article-1-86-en.html
Department of Obstetrics and Gynecology, School of Medicine, Kamali Hospital, Alborz University of Medical Sciences, Alborz, Iran
Abstract:   (111 Views)
Background & Aims: The prevalence of the mood or anxiety disorders during pregnancy is reported to be 18.2 %. This study aimed to investigate the effect of prenatal depression on childbirth and neonatal complications.
Materials & Methods: This cohort study selected 600 pregnant mothers who were referred to Kamali Alborz hospital in 2021 as the participants. These 600 pregnant woment were classified into three groups including: the group of pregnant mothers without depression whose Beck score was below 10, the group of pregnant mothers with untretaed prenatal depression whose Beck score was above 16, and the group of pregnant mothers with prenatal depression who were treated with selective serotonin reuptake inhibitors (SSRIs). There were 200 participants in each of the above-mentoned groups. These groups were compared with each other in terms of preterm labor, cesarean section, abortion, preeclampsia, birth weight, apgar, and NICU hospitalization status.
Results: In our study, the number of infants with low birth weight in the group of mothers with untretaed prenatal depression was higher than the number of these infants in the group of normal mothers (p < 0.05). Nontheless, there was not a significant differences between the groups in terms of the premature births (p = 0.092).  The rate of cesarean sectionwas higher in the group of mothers with untreated prenatal depression compared to the group of mothers who were treated with SSRIs. Moreover, this rate in both of these groups was higher than cesarian section rate in the group of the normal mothers (p < 0.05). The number of the infants who were hospitalized in the NICU was significantly higher in the SSRIs group (p < 0.05) compared to the other groups. Finally, the number of infants with 1-minute Apgar<7 was significantly higher in the group of mothers who were treated with SSRIs than the group of normal mothers (p = 0.126).
Conclusion: According to the results, cesarean section, premature birth, birth weight, and abortion were more satidfactory in the group of non-depressed mothers and the group of the depressed mothers who were treated with SSRIs in comparison with the group of the depressed mothes with ntreated depression.
Full-Text [PDF 273 kb]   (37 Downloads)    
Type of Study: Research | Subject: Special
Received: 2022/11/14 | Accepted: 2022/11/14 | Published: 2023/01/20

1. Uguz F, Yakut E, Aydogan S, Bayman MG, Gezginc K. Prevalence of mood and anxiety disorders during pregnancy: A case-control study with a large sample size. Psychiatry Research. 2019;272:316-8. [DOI] [PMID]
2. Lautarescu A, Craig MC, Glover V. Prenatal stress: Effects on fetal and child brain development. International review of neurobiology. 2020 Jan 1;150:17-40. [DOI] [PMID]
3. Fela-Thomas AL, Nna EO, Anyahara N, Ojo OT, Motilewa O, Okoh EE, et al. Use of Selective Serotonin Reuptake Inhibitors During Pregnancy and Prevalence of Congenital Malformations: A Protocol for Systematic Review and Meta-analysis of Observational Studies from 2009-2020. 2020. [DOI]
4. Dagher RK, Bruckheim HE, Colpe LJ, Edwards E, White DB. Perinatal depression: Challenges and opportunities. Journal of Women's Health. 2020. [DOI] [PMID] [PMCID]
5. Benatar S, Cross-Barnet C, Johnston E, Hill I. Prenatal depression: assessment and outcomes among medicaid participants. The Journal of Behavioral Health Services & Research. 2020:1-15. [DOI] [PMID]
6. Grote NK, Bridge JA, Gavin AR, Melville JL, Iyengar S, Katon WJ. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Archives of general psychiatry. 2010;67(10):1012-24. [DOI] [PMID] [PMCID]
7. Fujioka JK, Budhwani S, Thomas-Jacques T, De Vera K, Challa P, Fuller K, et al. Challenges and Strategies for Promoting Health Equity in Virtual Care: Protocol for a Scoping Review of Reviews. JMIR research protocols. 2020;9(12):e22847. [DOI] [PMID] [PMCID]
8. Milgrom J, Gemmill AW, Bilszta JL, Hayes B, Barnett B, Brooks J, et al. Antenatal risk factors for postnatal depression: a large prospective study. Journal of affective disorders. 2008;108(1-2):147-57. [DOI] [PMID]
9. Robertson E, Grace S, Wallington T, Stewart DE. Antenatal risk factors for postpartum depression: a synthesis of recent literature. General hospital psychiatry. 2004;26(4):289-95. [DOI] [PMID]
10. Alder J, Fink N, Bitzer J, Hösli I, Holzgreve W. Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. The Journal of Maternal-Fetal & Neonatal Medicine. 2007;20(3):189-209. [DOI] [PMID]
11. Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. The Canadian Journal of Psychiatry. 2004;49(11):726-35. [DOI] [PMID]
12. Yonkers KA, Wisner KL, Stowe Z, Leibenluft E, Cohen L, Miller L, et al. Management of bipolar disorder during pregnancy and the postpartum period. American Journal of Psychiatry. 2004;161(4):608-20. [DOI] [PMID]
13. Weinstock M. The potential influence of maternal stress hormones on development and mental health of the offspring. Brain, behavior, and immunity. 2005;19(4):296-308. [DOI] [PMID]
14. Ghajari H, Nouhjah S, Shahbazian H, Tahery N. Postpartum glucose testing, related factors and progression to abnormal glucose tolerance in a rural population with a known history of gestational diabetes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2017 Nov 1;11:S455-8. [DOI] [PMID]
15. Boyd RC, Zayas LH, McKee MD. Mother-infant interaction, life events and prenatal and postpartum depressive symptoms among urban minority women in primary care. Maternal and Child Health Journal. 2006;10(2):139. [DOI] [PMID]
16. Alizadeh M, Rahimi MM. Immediate successful renal autotransplantation after proximal ureteral avulsion fallowing ureteroscopy: a case report. Journal of Surgical Case Reports. 2017 Jan 1;2017(2): rjx028. [DOI] [PMID] [PMCID]
17. Rotem-Kohavi N, Williams LJ, Oberlander TF. Advanced neuroimaging: A window into the neural correlates of fetal programming related to prenatal exposure to maternal depression and SSRIs. InSeminars in perinatology 2020 Apr 1 (Vol. 44, No. 3, p. 151223). WB Saunders. [DOI] [PMID]
18. Figueiredo B, Pinto TM, Pacheco A, Field T. Fetal heart rate variability mediates prenatal depression effects on neonatal neurobehavioral maturity. Biological psychology. 2017;123:294-301. [DOI] [PMID]
19. Madigan S, Oatley H, Racine N, Fearon RP, Schumacher L, Akbari E, et al. A meta-analysis of maternal prenatal depression and anxiety on child socioemotional development. Journal of the American Academy of Child & Adolescent Psychiatry. 2018;57(9):645-57. e8. [DOI] [PMID]
20. Kassier SM, Madlala SS. Antenatal and postpartum depression: effects on infant and young child health and feeding practices. South African Journal of Clinical Nutrition. 2018 Mar 1;31(1):17-22. [DOI]
21. Karadag O, Aktas S. Optimal sample size determination for ANOVA designs. International Journal of Applied Mathematics and Statistics. 2012;25(1):127-34. [Google Scholar]
22. Koren G, Madjunkova S, Maltepe C. The protective effects of nausea and vomiting of pregnancy against adverse fetal outcome-a systematic review. Reproductive toxicology. 2014;47:77-80. [DOI] [PMID]
23. El Marroun H, Jaddoe VW, Hudziak JJ, Roza SJ, Steegers EA, Hofman A, et al. Maternal use of selective serotonin reuptake inhibitors, fetal growth, and risk of adverse birth outcomes. Archives of general psychiatry. 2012;69(7):706-14. [DOI] [PMID]
24. Grzeskowiak LE, Gilbert AL, Morrison JL. Neonatal outcomes after late-gestation exposure to selective serotonin reuptake inhibitors. Journal of clinical psychopharmacology. 2012;32(5):615-21. [DOI] [PMID]
25. Lund N, Pedersen LH, Henriksen TB. Selective serotonin reuptake inhibitor exposure in utero and pregnancy outcomes. Archives of pediatrics & adolescent medicine. 2009;163(10):949-54. [DOI] [PMID]
26. Wisner KL, Sit DK, Hanusa BH, Moses-Kolko EL, Bogen DL, Hunker DF, et al. Major depression and antidepressant treatment: impact on pregnancy and neonatal outcomes. American Journal of psychiatry. 2009;166(5):557-66. [DOI] [PMID] [PMCID]
27. Orr ST, James SA, Blackmore Prince C. Maternal prenatal depressive symptoms and spontaneous preterm births among African-American women in Baltimore, Maryland. American journal of epidemiology. 2002;156(9):797-802. [DOI] [PMID]
28. Ogunyemi D, Jovanovski A, Liu J, Friedman P, Sugiyama N, Creps J, et al. The contribution of untreated and treated anxiety and depression to prenatal, intrapartum, and neonatal outcomes. American Journal of Perinatology Reports. 2018;8(03):e146-e57. [DOI] [PMID] [PMCID]
29. Navaratne P, Foo XY, Kumar S. Impact of a high Edinburgh Postnatal Depression Scale score on obstetric and perinatal outcomes. Scientific reports. 2016;6(1):1-5. [DOI] [PMID] [PMCID]
30. Andersson L, Sundström-Poromaa I, Wulff M, Åström M, Bixo M. Implications of antenatal depression and anxiety for obstetric outcome. Obstetrics & Gynecology. 2004;104(3):467-76. [DOI] [PMID]
31. Biaggi A, Conroy S, Pawlby S, Pariante CM. Identifying the women at risk of antenatal anxiety and depression: a systematic review. Journal of affective disorders. 2016;191:62-77. [DOI] [PMID] [PMCID]
32. Wallis AB, Saftlas AF. Is there a relationship between prenatal depression and preeclampsia?: Oxford University Press; 2009. [DOI] [PMID]
33. Kurki T, Hiilesmaa V, Raitasalo R, Mattila H, Ylikorkala O. Depression and anxiety in early pregnancy and risk for preeclampsia. Obstetrics & Gynecology. 2000;95(4):487-90. https://doi.org/10.1097/00006250-200004000-00003 [DOI]
34. Qiu C, Sanchez SE, Lam N, Garcia P, Williams MA. Associations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study. BMC women's health. 2007;7(1):1-7. [DOI] [PMID] [PMCID]
35. Kjaersgaard MIS, Parner ET, Vestergaard M, Sørensen MJ, Olsen J, Christensen J, et al. Prenatal antidepressant exposure and risk of spontaneous abortion-a population-based study. PloS one. 2013;8(8):e72095. [DOI] [PMID] [PMCID]
36. Berkman DS, Lescano AG, Gilman RH, Lopez SL, Black MM. Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. The Lancet. 2002;359(9306):564-71. [DOI] [PMID]
37. Rahman A, Bunn J, Lovel H, Creed F. Association between antenatal depression and low birthweight in a developing country. Acta Psychiatrica Scandinavica. 2007;115(6):481-6. [DOI] [PMID] [PMCID]
38. Hermon N, Wainstock T, Sheiner E, Golan A, Walfisch A. Impact of maternal depression on perinatal outcomes in hospitalized women-a prospective study. Archives of women's mental health. 2019;22(1):85-91. [DOI] [PMID]
39. Pawluski JL, Brain UM, Underhill CM, Hammond GL, Oberlander TF. Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function. Psychoneuroendocrinology. 2012;37(7):1019-28. [DOI] [PMID]
40. Nordeng H, Lindemann R, Perminov K, Reikvam A. Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors. Acta Paediatrica. 2001;90(3):288-91. https://doi.org/10.1111/j.1651-2227.2001.tb00306.x [DOI] [PMID]
41. Levinson-Castiel R, Merlob P, Linder N, Sirota L, Klinger G. Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants. Archives of pediatrics & adolescent medicine. 2006;160(2):173-6. [DOI] [PMID]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 All Rights Reserved | Health Science Monitor

Designed & Developed by : Yektaweb