Volume 4, Issue 1 (January 2025)
Health Science Monitor 2025, 4(1): 7-14 |
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Taavon M, Tanhaei Marand V, Feizollahzadeh S. Evaluation of COVID-19 vaccination status and immune response among staff at Shahid Motahari Hospital, Urmia, 2021. Health Science Monitor 2025; 4 (1) :7-14
URL: http://hsm.umsu.ac.ir/article-1-191-en.html
URL: http://hsm.umsu.ac.ir/article-1-191-en.html
Assistant Professor, Department of Biology, Urmia Branch, Islamic Azad University, Urmia, Iran
Abstract: (483 Views)
Background & Aims: The Ministry of Health and Treatment implemented vaccination as one of the primary strategies to control the coronavirus disease 2019 (COVID-19) pandemic. Given their critical role in treatment and disease control, healthcare workers were prioritized for vaccination. This study aims to assess the vaccination status and level of immunity against COVID-19 among healthcare workers at Shahid Motahari Hospital in Urmia, Iran, in 2021.
Materials & Methods: A cross-sectional study was conducted with 150 volunteer healthcare workers at Shahid Motahari Hospital. Venous blood samples were collected to measure severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies using the ELISA method. Data analysis was performed using version 16 of SPSS software.
Results: The participants had a mean age of 37.5 years, with 47.3% being male. A significant 98% of the participants were vaccinated against COVID-19. The predominant vaccines administered were Sputnik V (72%), AstraZeneca (54%), and Sinopharm (27%). The mean level of SARS-CoV-2 neutralizing antibodies was significantly higher in vaccinated individuals compared to unvaccinated individuals (p = 0.001). There was no significant difference in antibody levels between male and female participants (p = 0.67). A positive correlation was observed between the number of vaccine doses received and the level of neutralizing antibodies (R = 0.207).
Conclusion: Vaccination with the mentioned vaccines, whether administered singly or in combination, effectively increased serum antibody levels, providing sufficient protection against COVID-19 for healthcare workers. To maintain immunity levels among healthcare workers and protect against emerging strains of the virus, it is essential to administer booster doses.
Materials & Methods: A cross-sectional study was conducted with 150 volunteer healthcare workers at Shahid Motahari Hospital. Venous blood samples were collected to measure severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies using the ELISA method. Data analysis was performed using version 16 of SPSS software.
Results: The participants had a mean age of 37.5 years, with 47.3% being male. A significant 98% of the participants were vaccinated against COVID-19. The predominant vaccines administered were Sputnik V (72%), AstraZeneca (54%), and Sinopharm (27%). The mean level of SARS-CoV-2 neutralizing antibodies was significantly higher in vaccinated individuals compared to unvaccinated individuals (p = 0.001). There was no significant difference in antibody levels between male and female participants (p = 0.67). A positive correlation was observed between the number of vaccine doses received and the level of neutralizing antibodies (R = 0.207).
Conclusion: Vaccination with the mentioned vaccines, whether administered singly or in combination, effectively increased serum antibody levels, providing sufficient protection against COVID-19 for healthcare workers. To maintain immunity levels among healthcare workers and protect against emerging strains of the virus, it is essential to administer booster doses.
Type of Study: Research |
Subject:
Health Protection including control of communicable and non-communicable diseases
Received: 2024/08/26 | Accepted: 2024/12/8 | Published: 2025/02/27
Received: 2024/08/26 | Accepted: 2024/12/8 | Published: 2025/02/27
References
1. Yeyati, E.L, F. Filippini. Social and economic impact of COVID-19. Brookings Institution. 2021. [Google Scholar]
2. Mohamadian M, Chiti H, Shoghli A, Biglari S, Parsamanesh N, Esmaeilzadeh A. COVID‐19: Virology, biology and novel laboratory diagnosis. The Journal of Gene Medicine. 2021; 23(2); p. e3303. [DOI] [PMID] [PMCID]
3. Forchette L, Sebastian W, Liu T. A comprehensive review of COVID-19 virology, vaccines, variants, and therapeutics. Current Medical Science. 2021; p. 1-15. [DOI] [PMID] [PMCID]
4. Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, et al. Immunology of COVID-19: current state of the science. Immunity. 2020; 52(6); p. 910-941. [DOI] [PMID] [PMCID]
5. Sokolowska M, Lukasik ZM, Agache I, Akdis CA, Akdis D, Akdis M, et al. Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics, and perspectives-a report of the European Academy of Allergy and Clinical Immunology (EAACI). Allergy. 2020; 75(10); p. 2445-2476. [DOI] [PMID] [PMCID]
6. Sethi A, H Bach. Evaluation of current therapies for COVID-19 treatment. Microorganisms. 2020; 8(8); p. 1097. [DOI] [PMID] [PMCID]
7. Yigit M, Ozkaya-Parlakay A, Senel E. Senel, Evaluation of COVID-19 vaccine refusal in parents. The Pediatric Infectious Disease journal. 2021; 40(4); p. e134-e136. [DOI] [PMID]
8. Gallasch CH, Cunha ML da, Pereira LA de S, Silva-Junior JS. Prevention related to the occupational exposure of health professionals workers in the COVID-19 scenario. Revista Enfermagem UERJ. 2020; p. 49596-49596. http://dx.doi.org/10.12957/reuerj.2020.49596 [DOI]
9. Zare H, Rezapour H, Mahmoodzadeh S, Fereidouni M. Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran. International Immunopharmacology. 2021; 101; p. 108351. [DOI] [PMID] [PMCID]
10. Bashirian S, Jenabi E, Khazaei S, Barati M, Karimi-Shahanjarini A, Zareian S, et al. Factors associated with preventive behaviours of COVID-19 among hospital staff in Iran in 2020: an application of the Protection Motivation Theory. Journal of Hospital Infection. 2020; 105(3); p. 430-433. [DOI] [PMID] [PMCID]
11. Kamali K, Hoseinzade Z, Hajimiri K, Hoveidamanesh S, Zahraei SM, Gouya MM, et al. Determinants of COVID-19 vaccine acceptance in healthcare workers in Iran: National Survey. BioMed Central Infectious Diseases. 2022; 22(1); p. 703. [DOI] [PMID] [PMCID]
12. Mirahmadizadeh A, Mehdipour Namdar Z, Miyar A, Maleki Z, Hashemi Zadehfard Hagheghe L, Sharifi MH. COVID-19 vaccine acceptance and its risk factors in Iranian health workers 2021. Iranian Journal of Medical Sciences. 2022; 47(5); p. 461. [DOI]
13. Omidvar S, Firouzbakht M. Acceptance of COVID-19 vaccine and determinant factors in the Iranian population: a web-based study. BioMed Central Health Services Research. 2022; 22(1); p. 1-8. [DOI] [PMID] [PMCID]
14. Pourakbari B, Mirbeyk M, Mahmoudi S, Hosseinpour Sadeghi RH, Rezaei N, Ghasemi R, et al. Evaluation of response to different COVID‐19 vaccines in vaccinated healthcare workers in a single center in Iran. Journal of Medical Virology. 2022; 94(12); p. 5669-5677. [DOI] [PMID] [PMCID]
15. Sammartino JC, Cassaniti I, Ferrari A, Giardina F, Ferrari G, Zavaglio F, et al. Evaluation of the neutralizing antibodies response against 14 SARS-CoV-2 variants in BNT162b2 vaccinated naïve and COVID-19 positive healthcare workers from a northern Italian hospital. Vaccines. 2022; 10(5); p. 703. [DOI] [PMID] [PMCID]
16. Jacot D, von Rotz U, Pellaton C, Blondet F, Aebischer O, Perreau M, et al. SARS-CoV-2 neutralizing antibody response in vaccinated and non-vaccinated hospital healthcare workers with or without history of infection. Microbes and Infection. 2023; 25(1-2); p. 105077. [DOI] [PMID] [PMCID]
17. Dinc HO, Saltoglu N, Can G, Balkan II, Budak B, Ozbey D, et al. Inactive SARS-CoV-2 vaccine generates high antibody responses in healthcare workers with and without prior infection. Vaccine. 2022; 40(1); p. 52-58. [DOI] [PMID] [PMCID]
18. Adjobimey T, Meyer J, Sollberg L, Bawolt M, Berens C, Kovačević P, et al. Comparison of IgA, IgG, and neutralizing antibody responses following immunization with Moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and Sinopharm's COVID-19 vaccines. Frontiers in Immunology. 2022; 13; p. 3094. [DOI] [PMID] [PMCID]
19. Claro F, Silva D, Pérez Bogado JA, Rangel HR, de Waard JH. Lasting SARS-CoV-2 specific IgG Antibody response in health care workers from Venezuela, 6 months after vaccination with Sputnik V. International Journal of Infectious Diseases. 2022; 122; p. 850-854. [DOI] [PMID] [PMCID]
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