Volume 1, Issue 2 (November 2022)                   Health Science Monitor 2022, 1(2): 116-124 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kazempour Dizaji M, Moniri A, Roozbahani R, Varahram M, Tabarsi P, Zare A, et al . Application of artificial neural network model in studying the mechanism of disease relapse event in patients with tuberculosis. Health Science Monitor 2022; 1 (2) :116-124
URL: http://hsm.umsu.ac.ir/article-1-59-en.html
Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran& Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD) , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1518 Views)
Background & Aims: Today, due to progressing technology and improving the standard of living of humans, the study of diseases has become more complex. This complexity has led to using new methods, such as the model of artificial neural networks (ANNs), to study many chronic diseases, especially tuberculosis (TB). The present study aimed to investigate the mechanism of disease relapse events by applying a multilayer perceptron artificial neural network (MLP-ANN) model among TB patients.
Materials & Methods: This retrospective cohort study examined information of 4,564 TB patients treated in Masih Daneshvari Hospital, Tehran, Iran, from 2005 to 2015. TB disease relapse was considered as a study event, and the relapse mechanism was investigated using an MLP-ANN model consisting of three layers.
Results: Based on an MLP-ANN model comprising three layers, the power to accurately predict disease relapse in TB patients was 96%. Also, variables of family size, adverse effects of exposure to cigarette smoke, patient age, and education as very effective factors, and marital status, history of drug use, imprisonment, pulmonary TB, diabetes, and AIDS as effective factors were identified in predicting the mechanism of TB disease relapse.
Conclusion: Using an ANN model in the study of TB relapse due to its flexibility and high predictive accuracy can clarify any ambiguous aspects of this disease.
 
Full-Text [PDF 454 kb]   (1155 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/08/20 | Accepted: 2022/10/19 | Published: 2022/11/19

References
1. Organization, WH, Global tuberculosis report. 2015. p. 204. [Google Scholar]
2. Diacon AH, Pym A, Grobusch MP, de los Rios JM, Gotuzzo E, Vasilyeva I, Leimane V, Andries K, Bakare N, De Marez T, Haxaire-Theeuwes M. Multidrug-resistant tuberculosis and culture conversion with bedaquiline. New England Journal of Medicine. 2014 Aug 21;371(8):723-32. [DOI] [PMID]
3. Quy HT, Lan NT, Borgdorff MW, Grosset J, Linh PD, Tung LB, van Soolingen D, Raviglione M, Co NV, Broekmans J. Drug resistance among failure and relapse cases of tuberculosis: is the standard re-treatment regimen adequate?. The International Journal of Tuberculosis and Lung Disease. 2003 Jul 1;7(7):631-6. [Google Scholar]
4. Sevim T, Atac G, Güngör G, Törün T, Aksoy E, Gemci I, Tahaoglu K. Treatment outcome of relapse and defaulter pulmonary tuberculosis patients. The International Journal of Tuberculosis and Lung Disease. 2002 Apr 1;6(4):320-5. [Google Scholar]
5. Farley JE, Ram M, Pan W, Waldman S, Cassell GH, Chaisson RE, Weyer K, Lancaster J, Van der Walt M. Outcomes of multi-drug resistant tuberculosis (MDR-TB) among a cohort of South African patients with high HIV prevalence. PloS one. 2011 Jul 22;6(7):e20436. [DOI] [PMID] [PMCID]
6. Pietersen E, Ignatius E, Streicher EM, Mastrapa B, Padanilam X, Pooran A, Badri M, Lesosky M, van Helden P, Sirgel FA, Warren R. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. The Lancet. 2014 Apr 5;383(9924):1230-9. [DOI] [PMID]
7. Salaniponi FM, Nyirenda TE, Kemp JR, Squire SB, Godfrey-Faussett P, Harries AD. Characteristics, management and outcome of patients with recurrent tuberculosis under routine programme conditions in Malawi. The international journal of tuberculosis and lung disease. 2003 Oct 1;7(10):948-52. [Google Scholar]
8. Organization, WH, Global tuberculosis control: WHO report 2010. 2010: World Health Organization. [URL]
9. Organization, W.H., Anti-tuberculosis drug resistance in the world: third global report. 2004. [Google Scholar]
10. Akl A, Ismail AM, Ghoneim M. Prediction of graft survival of living-donor kidney transplantation: nomograms or artificial neural networks?. Transplantation. 2008 Nov 27;86(10):1401-6. [DOI] [PMID]
11. Chi CL, Street WN, Wolberg WH. Application of artificial neural network-based survival analysis on two breast cancer datasets. InAMIA annual symposium proceedings 2007 (Vol. 2007, p. 130). American Medical Informatics Association. [PMID] [PMCID]
12. Yegnanarayana B. Artificial neural networks. 2009: PHI Learning Pvt. [Google Books]
13. Mirsaeidi SM, Tabarsi P, Khoshnood K, Pooramiri MV, Rowhani-Rahbar A, Mansoori SD, Masjedi H, Zahirifard S, Mohammadi F, Farnia P, Masjedi MR. Treatment of multiple drug-resistant tuberculosis (MDR-TB) in Iran. International journal of infectious diseases. 2005 Nov 1;9(6):317-22. [DOI] [PMID]
14. Wright A, Zignol M. Anti-tuberculosis drug resistance in the world: fourth global report: the world health organization/international :union: against tuberculosis and lung disease (who/:union:) global project on anti-tuberculosis drug resistance surveillance, 2002-2007. World Health Organization; 2008. [Google Books]
15. Mirsaeidi MS, Tabarsi P, Farnia P, Ebrahimi G, Morris MW, Masjedi MR, Velayati AA, Mansouri D. Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran. Saudi medical journal. 2007 Apr 1;28(4):544. [Google Scholar]
16. Mansoori, S., et al., Comparative study of initial and acquired drug resistance in pulmonary tuberculosis. Revue internationale des services de santé des forces armées, 2003. 76(1): p. 45-49. [Google Scholar]
17. Sargent DJ. Comparison of artificial neural networks with other statistical approaches: results from medical data sets. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2001 Apr 15;91(S8):1636-42. https://doi.org/10.1002/1097-0142(20010415)91:8+<1636::AID-CNCR1176>3.0.CO;2-D [DOI] [PMID]
18. Ahmed FE. Artificial neural networks for diagnosis and survival prediction in colon cancer. Molecular cancer. 2005 Dec;4(1):1-2. [DOI] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 All Rights Reserved | Health Science Monitor

Designed & Developed by : Yektaweb