Health Science Monitor

en Application of artificial neural network model in studying the mechanism of disease relapse event in patients with tuberculosis عمومى General پژوهشي Research Article Background & Aims: Today, due to progressing technology and improving the standard of living of humans, the study of diseases has become more complex. This complexity has led to using new methods, such as the model of artificial neural networks (ANNs), to study many chronic diseases, especially tuberculosis (TB). The present study aimed to investigate the mechanism of disease relapse events by applying a multilayer perceptron artificial neural network (MLP-ANN) model among TB patients. Materials & Methods: This retrospective cohort study examined information of 4,564 TB patients treated in Masih Daneshvari Hospital, Tehran, Iran, from 2005 to 2015. TB disease relapse was considered as a study event, and the relapse mechanism was investigated using an MLP-ANN model consisting of three layers. Results: Based on an MLP-ANN model comprising three layers, the power to accurately predict disease relapse in TB patients was 96%. Also, variables of family size, adverse effects of exposure to cigarette smoke, patient age, and education as very effective factors, and marital status, history of drug use, imprisonment, pulmonary TB, diabetes, and AIDS as effective factors were identified in predicting the mechanism of TB disease relapse. Conclusion: Using an ANN model in the study of TB relapse due to its flexibility and high predictive accuracy can clarify any ambiguous aspects of this disease.   Artificial neural networks, Perceptron, Relapse, Tuberculosis 116 124 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-76-3&slc_lang=en&sid=1 Mehdi Kazempour Dizaji mehdikazempourdizaji@gmail.com 10031947532846001524 10031947532846001524 Yes Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran& Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD) , Shahid Beheshti University of Medical Sciences, Tehran, Iran Afshin Moniri mehdikazempourdizaji@gmail.com 10031947532846001525 10031947532846001525 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Rahim Roozbahani mehdikazempourdizaji@gmail.com 10031947532846001526 10031947532846001526 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Varahram mehdikazempourdizaji@gmail.com 10031947532846001527 10031947532846001527 No Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Payam Tabarsi mehdikazempourdizaji@gmail.com 10031947532846001528 10031947532846001528 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ali Zare mehdikazempourdizaji@gmail.com 10031947532846001529 10031947532846001529 No Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD) , Shahid Beheshti University of Medical Sciences, Tehran, Iran Parvaneh Baghaei Shiva mehdikazempourdizaji@gmail.com 10031947532846001530 10031947532846001530 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Atefe Abedini mehdikazempourdizaji@gmail.com 10031947532846001531 10031947532846001531 No Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Majid Marjani mehdikazempourdizaji@gmail.com 10031947532846001532 10031947532846001532 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammadreza Madani mehdikazempourdizaji@gmail.com 10031947532846001533 10031947532846001533 No Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Arda Kiani 10031947532846001534 10031947532846001534 No Tracheal Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Ali Emamhadi 10031947532846001535 10031947532846001535 No Department Forensic Medicine, School of Medicine Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloufar Alizadeh Kolahdozi mehdikazempourdizaji@gmail.com 10031947532846001536 10031947532846001536 No Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD) , Shahid Beheshti University of Medical Sciences, Tehran, Iran