en ارتقای سلامت، پیشگیری و کنترل بیماری‌ ها Health Promotion, Protection, and Disease Control نامه به سردبیر Letter to Editor <span style="font-size:12px;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span new="" roman="" times="">Dear Editor,</span><br> <span new="" roman="" times="">Hantavirus infection remains a serious zoonotic illness that causes serious problems in the human heart, lungs, and kidneys. The virus is usually spread through the inhalation of aerosolized particles contaminated with rodent urine, saliva, or feces, and it has been identified as a public health threat in various countries across the world. Hantavirus infections have been reported across Asia, Europe, and the Americas, with thousands of cases of hemorrhagic fever with renal syndrome (HFRS) occurring annually worldwide. In the Americas, hantavirus cardiopulmonary syndrome (HCPS) remains a rare but highly fatal disease, with reported case-fatality rates often exceeding 30%. Despite extensive research on the epidemiology, transmission, and clinical manifestations of hantavirus infection, the potential role of physical activity in prevention and recovery remains underexplored.</span><br> <span new="" roman="" times="">Regular physical activity is widely recognized as an important modulator of immune function. Exercise at a moderate level has been demonstrated to promote immune cell circulation, strengthen immunological surveillance, and lessen persistent systemic inflammation. Previous studies suggest that physically active individuals may be less susceptible to infectious diseases and may experience improved outcomes following viral infections, according to earlier research. Additionally, exercise improves pulmonary and cardiovascular health, which may be especially important in cases of HCPS, where respiratory compromise is a significant clinical problem.</span><br> &nbsp;</span></span></span> Immunomodulation, Physical activity, Prevention and control, Rehabilitation, Hantavirus infections 1 3 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-365-2&slc_lang=en&sid=1 Narges Yazdan Nasab nargesyazdannasab@uma.ac.ir 10031947532846004960 0009-0000-6886-6570 No Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran Amir Hossein Hormati Oughoulbaig Amirhosseinhormati@uma.ac.ir 10031947532846004961 0009-0001-1281-0612 Yes Department of Sport Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran Asadollah Asadi Asady@uma.ac.ir 10031947532846004962 10031947532846004962 No Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran