en تخصصي Special پژوهشي Research Article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">Introduction: Pre-labour rupture of membranes is a critical obstetric condition, presenting an important contribution to maternal and neonatal morbidity and mortality. This study aims to investigate the diagnostic value of vaginal fluid creatinine in the identification of PROM. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> In the present descriptive-analytical study, 150 pregnant women were recruited and randomly assigned to three groups: confirmed PROM (n=50), suspected PROM (n=50), and healthy controls (n=50). Vaginal fluid samples were collected and analyzed for creatinine concentration using the Jaffe technique. Data were analyzed with SPSS version 16, employing ANOVA and post hoc tests. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> Mean creatinine level of vaginal fluid was significantly higher in the PROM group compared with the control group (p < 0.05). Tukey post hoc test showed significant creatinine level groupings between PROM cases and controls. Maternal age, gestational age, and fetal weight did not show a significant correlation with creatinine levels (p > 0.05). Creatinine testing demonstrated higher diagnostic accuracy compared to the Fern test with a moderate correlation rate of 54%. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">The measurement of creatinine in vaginal fluid is an inexpensive, quick, and dependable diagnostic test for PROM, which is superior to the Fern test. Vaginal creatinine testing may also enhance maternal and neonatal outcomes due to the timeliness and accuracy of early diagnosis of PROM.</span></span></span></span> Creatinine, Premature rupture of membrane, vaginal discharge 368 375 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-290-1&slc_lang=en&sid=1 Neda Hamdolahpour 10031947532846003093 10031947532846003093 Yes Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Tahereh Behroozi-lak 10031947532846003094 10031947532846003094 No Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Sonia Sadeghpour 10031947532846003095 10031947532846003095 No Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran