en عمومى General گزارش مورد Case Report <p><span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background</span></i></b><b><span style="font-size:9.0pt">: </span></b>&nbsp;<span style="font-size:9.0pt">Proton pump inhibitors (PPIs) are used by 50.85%, 42.16%, and 40.97% of doctors, nurses, and pharmacists, respectively. The reported incidence of anaphylaxis with PPIs is under 1%.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Case Presentation: </span></i></b><span style="font-size:9.0pt">We present the first-ever reported case of anaphylaxis to pantoprazole, which failed medical management with multiple attempts for endotracheal and nasotracheal intubation failed due to diffuse edema, necessitating the need for an urgent tracheostomy and mechanical ventilation. Famotidine replaced pantoprazole throughout the hospital course, and he had no further hypersensitivity reactions.</span><span style="font-size:9.0pt"> &nbsp;</span></span></span></span><br> <b><i><span style="font-size:9.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">Conclusion</span></span></span></i><span style="font-size:9.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">: </span></span></span></b><span style="font-size:9.0pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times="">PPIs are effective but not without severe complications. Unfortunately, anaphylaxis is often misdiagnosed, increasing the risk of mortality and morbidity. Although anaphylaxis is rare, these reactions can be life-threatening. Emergency medicine and primary care physicians must be aware of the potential side effects of PPIs and should carefully monitor patients in inpatient and outpatient clinical settings.</span></span></span></p> Anaphylaxis, Pantoprazole, Proton pump inhibitor, Tracheostomy  1 6 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-288-1&slc_lang=en&sid=1 Dawood Tahir dawood.tahir@outlook.com 10031947532846003414 10031947532846003414 Yes Internal Medicine, Jefferson Abington Hospital, Abington, Pennsylvania, USA Ihtisham Haider Bhatti ihtzzahid@gmail.com 10031947532846003415 10031947532846003415 No Medical Officer, Fauji Foundation Hospital, Lahore, Pakistan Wardah Tariq wardahtariq63@gmail.com 10031947532846003416 10031947532846003416 No Demonstrator Biochemistry, Bakhtawar Amin Medical and Dental College, Multan, Pakistan Shravya Ginnaram Shravya.Ginnaram@jefferson.edu 10031947532846003417 10031947532846003417 No Transplant Hepatology Fellow, University of Nebraska Medical Center, Nebraska, USA Jacob Lipkin jacob.lipkin@jefferson.edu 10031947532846003418 10031947532846003418 No Gastroenterology, Jefferson Abington Hospital, Abington, Pennsylvania, USA