en عمومى General پژوهشي Research Article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:10.0pt">The s</span><span style="font-size:10.0pt">ynthetic testosterone analog nandrolone decanoate (ND) is one of the most commonly used anabolic androgenic steroids (AAS) among athletes and teens. Athletes who consume anabolic androgenic steroids regularly are more likely to develop liver issues, although the exact process is unknown. This experimental investigation aims to evaluate the impact of nandrolone decanoate treatment on the hepatic architecture of male rats.</span> <span style="font-size:9.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> For the purpose of this study, twenty male albino rats were separated into two groups. Group A received peanut oil as a control, whereas Group B received weekly injections of nandrolone decanoate at a dose of 10 mg/kg body weight for eight weeks. The rats were sacrificed after 8 weeks, following the guidelines provided by the Ethics Committee. After the rats were dissected, the liver tissue was collected and fixed in accordance with standard histological protocols. Hematoxylin and eosin were used to stain sections, and microscopic observations were recorded in both groups. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> After 8 weeks, microscopic examination of the liver in the control group revealed no noticeable changes, while the group treated with nandrolone decanoate displayed large Kupffer cells, vacuolation of the hepatocytes, congestion of the central vein, and dilatation of the hepatic sinusoids. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">The research showed that abusing nandrolone decanoate causes liver issues such as hepatic sinusoidal dilatation, congestion, and vacuolation of hepatocytes. It also causes congestion in the central vein. This research highlights the need for well-designed trials with appropriate dosage considerations, as well as the examination of the long-term effects of nandrolone decanoate<u>.</u></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:200%"><span sans-serif="" style="font-family:Calibri,"><u><span style="font-family:"Times New Roman","serif""></span></u></span></span></span> Anabolic androgenic steroids, Liver histopathology, Nandrolone decanoate 29 36 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-272-1&slc_lang=en&sid=1 Parvaiz Ahmad Lone parvaizgull01@gmail.com 10031947532846003433 10031947532846003433 No Senior Resident, Department of Anatomy, Government Medical College, Anantnag Bashir Ahmad Shah drbashirahmadshah@gmail.com 10031947532846003434 10031947532846003434 No Professor, Postgraduate Department of Anatomy, Government Medical College, Srinagar Nazish Aslam drnazishaslam7@gmail.com 10031947532846003435 0009-0008-7234-1636 No Senior Resident, Department of Anatomy, Government Medical College, Srinagar Mudasir Ahmad Khan drmudasirkhan73@gmail.com 10031947532846003436 0009-0007-6138-3104 Yes Assistant Professor, Department of Anatomy, Government Medical College, Anantnag