en تخصصي Special پژوهشي Research Article <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">&beta;-thalassemia is a severe hereditary disorder caused by defective globin synthesis. Patients suffering from &beta;-thalassemia major require regular blood transfusion therapy to survive. Sight-threatening ocular abnormalities are quite common among these patients. This study was planned to evaluate the prevalence of ocular complications in multi-transfused patients with &beta;-thalassemia who have been receiving deferoxamine. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">Thirty thalassemic patients receiving deferoxamine were studied in this cross-sectional descriptive study. All eligible subjects underwent an ophthalmologic examination, including the Humphrey visual field test, measurement of central corneal thickness (CCT), best-corrected visual acuity (BCVA), and central macular thickness (CMT).</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">Visual&nbsp;field defects were the most prevalent ocular abnormalities, observed in 50% of the studied subjects. Other ocular changes were as follows: bilateral cortical cataract (10%), macular pigmentary stippling (6.7%), punctate cortical opacity (3.3%), nuclear sclerosis cataract (3.3%), and macular pigmentary mottling (3.3%).</span> <b><span style="font-size:9.0pt"></span></b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">: </span></b><span style="font-size:9.0pt">The occurrence of ocular problems is common among thalassemic patients which necessitates long-term follow-up and regular ophthalmologic examination for these patients.</span></span></span></span> Cataract, Deferoxamine, Ocular manifestation, Thalassemia, Visual field defects 292 297 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1 Naser Samadi Aidenloo Dr.nasersamadi@yahoo.com 10031947532846003049 10031947532846003049 No Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Qader Motarjemizadeh motarjemizadeh.q@umsu.ac.ir 10031947532846003050 10031947532846003050 Yes Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Sina Hasani Shayan paryaab@yahoo.com 10031947532846003051 10031947532846003051 No Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran