en عمومى General پژوهشي Research Article <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Background & Aims</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> Atopic dermatitis (AD) has a detrimental impact on the quality of life (QoL) for both patients and their families. Our investigation delved into the correlation between the severity of the disease and the QoL experienced by individuals with AD.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Materials & Methods</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> This cross-sectional descriptive-analytical study included AD children, between 0 to 16 years of age, along with their parents. The influence of childhood AD on parents&#39; QoL was studied using several questionnaires, which measures four areas of physical health, mental health, social relations, and environmental health. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Results</span></i></b><b><span style="font-size:9.0pt">:</span></b><span style="font-size:9.0pt"> Of 100 AD children, 52% were boys and 48% were girls with a mean age of 5.96 &plusmn; 4.72 years. Ninety percent of children had moderate AD. The mean score of QoL for children aged 5-16 years (CDQOL questionnaire) was 17.51, and for children aged 0-4 years (IDQOL questionnaire) was 15.80. The mean score of parents&#39; QoL, according to the FDLQI questionnaire, was 13.90, and according to the DFI questionnaire, it was 6.39. The mean scores of health and QoL in four areas of physical health, mental health, social relations, and environmental health were 20.79, 17.75, 9.72, and 25.9, respectively. There was a significant correlation between disease severity and scores obtained from CDQOL and IDQOL questionnaires (<i>p</i> < 0.001). &nbsp;</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:16.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><i><span style="font-size:9.0pt">Conclusion</span></i></b><b><span style="font-size:9.0pt">:</span></b> <span style="font-size:9.0pt">Childhood AD had a greater impact on QoL of parents in the areas of social relationships and psychological well-being. The influence of AD on the QoL of family members is significant, and this should be taken into account in the therapeutic process.</span></span></span></span> Atopic dermatitis, Children, Disease severity, Quality of life 60 68 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-113-3&slc_lang=en&sid=1 Mona Nikpo monanikpou73@gmail.com 10031947532846002269 10031947532846002269 No Medical student, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Hamidreza Houshmand hamidreza.houshmnd@gmail.com 10031947532846002270 10031947532846002270 Yes Department of Allergy and Clinical Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Mir Reza Ghaemi dr.reza.ghaemi@gmail.com 10031947532846002271 10031947532846002271 No Department of Allergy and Clinical Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran Javad Rasouli rsljvd@yahoo.com 10031947532846002272 10031947532846002272 No Department of Epidemiology and Biostatistics, Urmia University of Medical Sciences, Urmia, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran