Health Science Monitor

en Evaluation of the time-dependent effects of factors influencing the hazard of disease recurrence in tuberculosis patients عمومى General پژوهشي Research Article Background & Aims: There are variables whose influence on the risk of tuberculosis (TB) recurrence change over time. Therefore, this study aimed to assess the time-dependent effects of these variables on the hazard of TB recurrence. Materials & Methods: In this historical cohort study, data were collected from 4,564 TB patients who were referred to the TB research center of Dr. Masih Daneshvari Hospital, Tehran, from 2005 to 2015, in order to evaluate factors affecting the hazard of TB recurrence in terms of time dependency or time constancy. Data were analyzed in STATA 14 software using a statistical test based on Schoenfeld residuals, the time-dependent effects method, and the time-varying effects model (considering time function as f (t) = t). Results: The results showed that only the impact of the variables of drug adverse effects and passive smoker were inconstant over time and had time-dependent effects, and they also influenced the hazard of TB recurrence. Also, the effect of the two mentioned variables on the hazard of TB recurrence displayed a decreasing and increasing trend with time, respectively. Conclusion: Using the time-varying effects model in the study of the hazard of TB recurrence allows evaluating the time-dependent effects of the studied variables and also can differentiate them from the time-independent variables. Recurrence, Time-dependent effects, Time-varying effects model, Tuberculosis 39 47 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-76-8&slc_lang=en&sid=1 Mehdi Kazempour Dizaji mehdikazempourdizaji@gmail.com 10031947532846002253 10031947532846002253 Yes Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Varahram mehdikazempourdizaji@gmail.com 10031947532846002254 10031947532846002254 No Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Atefe Abedini mehdikazempourdizaji@gmail.com 10031947532846002255 10031947532846002255 No Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Rahim Roozbahani mehdikazempourdizaji@gmail.com 10031947532846002256 10031947532846002256 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Zare mehdikazempourdizaji@gmail.com 10031947532846002257 10031947532846002257 No Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Payam Tabarsi mehdikazempourdizaji@gmail.com 10031947532846002258 10031947532846002258 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Majid Marjani mehdikazempourdizaji@gmail.com 10031947532846002259 10031947532846002259 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Afshin Moniri mehdikazempourdizaji@gmail.com 10031947532846002260 10031947532846002260 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloufar Alizadeh Kolahdozi mehdikazempourdizaji@gmail.com 10031947532846002261 10031947532846002261 No Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammadreza Madani mehdikazempourdizaji@gmail.com 10031947532846002262 10031947532846002262 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Parvaneh Baghaei Shiva mehdikazempourdizaji@gmail.com 10031947532846002263 10031947532846002263 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran