Health Science Monitor

en Prediction of multidrug-resistant tuberculosis in tuberculosis patients using perceptron artificial neural networks model عمومى General پژوهشي Research Article Background & Aims: Diagnosis and treatment of patients with multidrug-resistant tuberculosis (MDR-TB) are very important. Hence, it is necessary to predict and diagnose these patients based on individual, demographic and clinical characteristics before starting treatment. This study aimed to predict MDR-TB in TB patients using the perceptron artificial neural networks (ANNs) model. Materials & Methods: This retrospective cohort study was conducted on 1,050 TB patients who have been treated in Masih Daneshvari Hospital, Tehran, Iran from 2005 to 2015. Data on personal and demographic information, as well as medical data such as drug therapy, final outcome of treatment, and the diagnosis of MDR-TB, were collected from the patients' medical records. Results: The results of this study indicated that the predictive power of MDR-TB for both training and testing groups was 85% and 80%, respectively. Also, the variables of marital status, education, drug use, being imprisoned, extrapulmonary TB, history of comorbidities, AIDS, patients' age, and family size were identified as very effective factors. However, variables of residence, smoking history, contact with a TB person, pulmonary TB, drug side effects, nationality, and diabetes were found as effective factors in predicting the development of MDR-TB. Conclusion: Application of the perceptron ANNs model in the study of MDR-TB is able to create new horizons in the diagnosis of these patients due to high predictive accuracy. Artificial neural networks, Perceptron, Tuberculosis, Multidrug-resistant tuberculosis 90 98 http://hsm.umsu.ac.ir/browse.php?a_code=A-10-76-6&slc_lang=en&sid=1 Mehdi Kazempour Dizaji mehdikazempourdizaji@gmail.com 10031947532846001427 10031947532846001427 Yes Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Varahram mehdikazempourdizaji@gmail.com 10031947532846001428 10031947532846001428 No Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Payam Tabarsi mehdikazempourdizaji@gmail.com 10031947532846001429 10031947532846001429 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Rahim Roozbahani mehdikazempourdizaji@gmail.com 10031947532846001430 10031947532846001430 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Zare mehdikazempourdizaji@gmail.com 10031947532846001431 10031947532846001431 No Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Afshin Moniri mehdikazempourdizaji@gmail.com 10031947532846001432 10031947532846001432 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammadreza Madani mehdikazempourdizaji@gmail.com 10031947532846001433 10031947532846001433 No Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Atefe Abedini mehdikazempourdizaji@gmail.com 10031947532846001434 10031947532846001434 No Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Parvaneh Baghaei Shiva mehdikazempourdizaji@gmail.com 10031947532846001435 10031947532846001435 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Majid Marjani mehdikazempourdizaji@gmail.com 10031947532846001436 10031947532846001436 No Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloufar Alizadeh Kolahdozi mehdikazempourdizaji@gmail.com 10031947532846001437 10031947532846001437 No Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran